Frequently Asked Questions
PREMATURE OVARIAN FAILURE FAQS
Your common answers about premature ovarian failure available on this page!
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THE LOSS OF OVARIAN FUNCTION BELOW 40 YEARS IS CALLED PREMATURE OVARIAN FAILURE (POF)
What is premature ovarian failure ?
Most often, it is a non-reversible pathology.
What's the risk?
Its incidence increases with advancing age, being recognized in:
- 0.01% of women younger than 20 years;
- 0.1% of women younger than 30 years;
- 1% of women younger than 40 years.
What causes it?
- genetic, endocrine, paracrine, mitochondrial dysfunction-related, and metabolic factors affecting follicles and oocytes quality;
- chemotherapy, radiotherapy, and surgery;
- autoimmune reactions;
- viral or bacterial infections.
Should I see a doctor?
Symptoms requiring medical evaluation include new-onset menstrual irregularities (presenting either as infrequent menses or too frequent menstruation) and fertility issues.
What are the main treatments?
POF treatment can involve infertility therapy too. Moreover, fertility preservation after anticancer therapy can be achieved through:
- suppression of ovarian function prior to chemotherapy;
- re-transplantation of an in vitro activated ovary;
- cryopreservation of ovarian tissue, mature oocytes or embryos.
Mesenchymal stem cells transplantation aims at restore ovarian function. It improves hormone production, ovarian structure, endometrial thickness, and blood flow in the endometrium. It is an effective, tolerable, safe, and minimally immunogenic therapy. The use of autologous stem cells mitigate any immunogenic concern.
Adipose-derived mesenchymal stem cells are easy to isolate and expand. All is required are 20 cc of fat collected during a quick and painless outpatient procedure. Cells not immediately utilized can be cryopreserved for future treatment.